Phenotypes for Hoxb8 Hoxc8 Hoxd8 MGI:3610494 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hoxb8^tm1.1Jdes/? Hoxc8^tm1Phb/Hoxc8^tm1Phb Hoxd8^tm1Jdes/Hoxd8^tm1Jdes
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8^tm1.1Jdes mutation (0 available); any Hoxb8 mutation (8 available)
Hoxc8^tm1Phb mutation (0 available); any Hoxc8 mutation (8 available)
Hoxd8^tm1Jdes mutation (0 available); any Hoxd8 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal thoracic cage morphology ( J:68720 )

• upper ribcage abnormalities are much more prevalent

asymmetric sternocostal joints ( J:68720 )

• bilateral attachment of extra ribs to sternum is less common

increased rib number ( J:68720 )

• presence of L1 ribs less prevalent

thoracic vertebral transformation ( J:68720 )

• T8 to T7 transformation less frequent and not as severe as when Hoxc8^tm1Phb only was mutated

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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