Phenotypes Associated with This Genotype

Genotype
MGI:3610469

• Allelic Composition: Epb41l3^tm1Jkis/Epb41l3^tm1Jkis
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:102380 )

N • no alteration in cellular proliferation and apoptosis

reproductive system

reproductive system phenotype ( J:102380 )

N • homozygous mice are fertile

neoplasm

neoplasm ( J:102380 )

N • mice show no tendancy to increased tumor development

nervous system

abnormal paranodal axoglial junction morphology ( J:173383 )

• septate junction septa in sciatic nerves are normal at 3 months

• septate junction septa in sciatic nerves are missing at 6 and 12 months of age

• axolemma is essentially detached from myelin loops in the sciatic nerve at 1 year of age, no septa