Phenotypes Associated with This Genotype

Genotype
MGI:3610384

• Allelic Composition: Gnas^tm5.1Lsw/Gnas^tm5.1Lsw; Tg(Alb1-cre)1Dlr/?
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased liver weight ( J:102504 )

• approximately 25% greater than control

increased liver glycogen level ( J:102504 )

• in the fed state

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:102504 )

N • food intake measured over 14 days was normal

hypoglycemia ( J:102504 )

• in fed mutant mice

increased circulating glucagon level ( J:102504 )

• very high glucagon and glucagon-like peptide-1

decreased circulating insulin level ( J:102504 )

• in fed mutant mice

increased circulating triglyceride level ( J:102504 )

• in fasted mutant mice

abnormal energy expenditure ( J:102504 )

• mutant mice had resting and total energy expenditure rate at 30 degree

• resting or total energy expenditure rate or activity level at ambient temperature are normal

improved glucose tolerance ( J:102504 )

• increased glucose-stimulated insulin secretion

• increased insulin sensitivity in liver and muscle

increased liver glycogen level ( J:102504 )

• in the fed state

adipose tissue

decreased total body fat amount ( J:102504 )

• reduced adiposity

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:102504 )

• alpha cell hyperplasia with les uniform cellular size and appearance

increased pancreas weight ( J:102504 )

• mutant mice had increased pancreas weights

growth/size/body

increased pancreas weight ( J:102504 )

• mutant mice had increased pancreas weights

increased liver weight ( J:102504 )

• approximately 25% greater than control