Phenotypes Associated with This Genotype

Genotype
MGI:3609907

• Allelic Composition: Srd5a3^{Gt(OST436695)Lex}/Srd5a3^{Gt(OST436695)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:163281 )

• mice die between E11.5 and E13.5

preweaning lethality, complete penetrance ( J:103485 )

• no homozygotes seen at weaning; stage of lethality not specified

embryo

failure of initiation of embryo turning ( J:163281 )

• at E10.5, mice fail to rotate unlike wild-type mice

open neural tube ( J:163281 )

cardiovascular system

dilated heart ( J:163281 )

• at E10.5

nervous system

open neural tube ( J:163281 )

growth/size/body

abnormal ventral body wall morphology ( J:163281 )

• at E10.5