Phenotypes Associated with This Genotype

Genotype
MGI:3609475

• Allelic Composition: Aqp7^tm1.1Suc/Aqp7^tm1.1Suc
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine glucose level ( J:102454 )

• higher urine glucose levels than in wild-type, however plasma and urine urea levels are normal

abnormal kidney physiology ( J:102454 )

• water permeability of the brush-border membrane vesicles from the outer medulla is slightly but significantly lower than that of wild-type, however do not exhibit a urinary concentrating defect

homeostasis/metabolism

increased urine glucose level ( J:102454 )

• higher urine glucose levels than in wild-type, however plasma and urine urea levels are normal

reproductive system

reproductive system phenotype ( J:129600 )

N • contrary to expectation, 15-wk-old mutant males are fully fertile, with no significant differences in offspring number, testicular weight- and epididymal weight-to-body weight ratios, daily sperm production, sperm motility, sperm morphology and morphometry or in vitro fertilization capacity relative to wild-type males