Phenotypes Associated with This Genotype

Genotype
MGI:3609212

• Allelic Composition: Spi1^tm1Sing/Spi1⁺; Spib^tm1Mcs/Spib⁺
• Genetic Background: involves: 129S/SvEv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:88257 )

N

decreased B cell proliferation ( J:88257 )

• IgM cross-linking or pervanadate/H202 stimulation yields less than normal levels of tyrosine phosphorylation and IgM cross-linking also yields less calcium mobilization than normal

abnormal spleen germinal center morphology ( J:88257 )

• although the B cell profiles in spleen and lymph node are normal, there are small splenic germinal centers, and inability to maintain germinal centers

immune system

decreased B cell proliferation ( J:88257 )

• IgM cross-linking or pervanadate/H202 stimulation yields less than normal levels of tyrosine phosphorylation and IgM cross-linking also yields less calcium mobilization than normal

abnormal spleen germinal center morphology ( J:88257 )

• although the B cell profiles in spleen and lymph node are normal, there are small splenic germinal centers, and inability to maintain germinal centers

cellular

decreased B cell proliferation ( J:88257 )

• IgM cross-linking or pervanadate/H202 stimulation yields less than normal levels of tyrosine phosphorylation and IgM cross-linking also yields less calcium mobilization than normal