Mouse Genome Informatics
hm
    Fut8tm1Nta/Fut8tm1Nta
involves: 129S2/SvPas
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Growth retardation in Fut8tm1Nta/Fut8tm1Nta mice

mortality/aging
• about 70% die within 3 days of age

growth/size/body
• most homozygotes surviving past 3 days of age manifest severe growth retardation

respiratory system
• exhibit dilated alveolar ducts
• increase in the diameters of pulmonary alveoli from P7
• exhibit progressive emphysema-like changes, including impaired respiration and enhanced expression of matrix metalloproteases
• exhibit fragmentation and reduction in the number of elastic fibers in the lungs
• exhibit generalized air-space enlargement in the lungs
• lungs have larger total lung capacities
• display an increase in lung compliance
• under resting conditions, respiratory minute volume and rate are higher than in wild-type
• ventilatory responses to systemic hypoxia or hypercapnia, or increases in the respiratory minute volume, are significantly attenuated

Mouse Models of Human Disease
OMIM IDRef(s)
Emphysema, Hereditary Pulmonary 130700 J:102932