Phenotypes Associated with This Genotype

Genotype
MGI:3608891

• Allelic Composition: Gjc1^tm2Kni/Gjc1^tm2Kni; Tg(ACTC1-cre)1Miwa/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:103078 )

• mutants die around E10

cardiovascular system

abnormal placenta vasculature ( J:103078 )

• ingrowths of embryonic vessels are mostly normal but many areas of collapsed vessels are seen

thin myocardium ( J:103078 )

• thickness of the myocardial wall is less than wild-type but greater than mice homozygous for Gja7^tm2.1Kni

decreased cardiac output ( J:103078 )

• motion of the outflow tract is reduced or absent

abnormal impulse conducting system conduction ( J:103078 )

• a conduction block through the atrioventricular canal is present however the endocardial cushions are normal and blood flow through the atrioventricular canal is unidirectional

embryo

abnormal placenta vasculature ( J:103078 )

• ingrowths of embryonic vessels are mostly normal but many areas of collapsed vessels are seen

hematopoietic system

impaired hematopoiesis ( J:103078 )

• reduced hematopoiesis is seen in moribund embryos

nervous system

increased embryonic neuroepithelium apoptosis ( J:103078 )

• clusters of apoptotic cells are seen in the neuroepithelium

muscle

thin myocardium ( J:103078 )

• thickness of the myocardial wall is less than wild-type but greater than mice homozygous for Gja7^tm2.1Kni

cellular

increased embryonic neuroepithelium apoptosis ( J:103078 )

• clusters of apoptotic cells are seen in the neuroepithelium