Phenotypes Associated with This Genotype

Genotype
MGI:3608618

• Allelic Composition: Myo1c^tm1Pgg/Myo1c^tm1Pgg
• Genetic Background: B6.129S4-Myo1c^tm1Pgg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal vestibular hair cell physiology ( J:100987 )

• fast positive, fast negative, and slow negative adaptation are faster in homozygous hair cells compared to wild-type cells however the rate constant for slow positive adaptation is similar to wild-type cells

• N⁶(2-methyl butyl) ADP reduced the rate constant for fast positive, fast negative and slow negative adaptation, but does not alter the rate of any of these in wild-type cells

nervous system

abnormal vestibular hair cell physiology ( J:100987 )

• fast positive, fast negative, and slow negative adaptation are faster in homozygous hair cells compared to wild-type cells however the rate constant for slow positive adaptation is similar to wild-type cells

• N⁶(2-methyl butyl) ADP reduced the rate constant for fast positive, fast negative and slow negative adaptation, but does not alter the rate of any of these in wild-type cells