Phenotypes Associated with This Genotype

Genotype
MGI:3607588

• Allelic Composition: Bace1^tm1Psa/Bace1^tm1Psa
• Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:100925 )

• 19% die within the first 3-6 days of birth and 24% die by 3-4 weeks of age

growth/size/body

decreased body weight ( J:100925 )

• mice surviving to adulthood are about 30% smaller by weight than controls

cachexia ( J:100925 )

• the 24% that die by 3-4 weeks of age die from a wasting syndrome, although overall immune defense is normal

postnatal growth retardation ( J:100925 )

• the 24% that die by 3-4 weeks of age are growth retarded

behavior/neurological

decreased anxiety-related response ( J:100925 )

hyperactivity ( J:100925 )

nervous system

abnormal nervous system physiology ( J:100925 )

• neurons do not process APP at the known beta-secretase sites and thus do not produce any measurable Abeta, although glial cells do produce Abeta

abnormal channel response ( J:100925 )

• significant shift in steady-state inactivation of the Na⁺ current toward more depolarized potentials, indicating that a larger fraction of Na⁺ channels is available at a given potential compared to wild-type