Phenotypes Associated with This Genotype

Genotype
MGI:3607144

• Allelic Composition: Sorl1^tm1Tew/Sorl1^tm1Tew
• Genetic Background: either: (involves: 129/SvEmcTer * BALB/c) or (involves: 129/SvEmcTer * C57BL/6N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:101417 )

N • homozygotes are viable and fertile with no change in overall APP levels; however, neuron associated Abeta levels and production of sAPP in the brain are increased at 10 months of age

amyloid beta deposits ( J:101417 )

• increase in levels of amyloid beta peptide in the brain

homeostasis/metabolism

amyloid beta deposits ( J:101417 )

• increase in levels of amyloid beta peptide in the brain