Phenotypes Associated with This Genotype

Genotype
MGI:3607127

• Allelic Composition: Tg(SERPINA1-Tnfsf12)1Biib/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal oval cell morphology ( J:100907 )

• increased numbers of ovals cells are seen at 2 weeks of age and by 8 weeks through 5-8 months a high number of cells organized in either single file or irregularly shaped duct-like structures are seen

abnormal liver physiology ( J:100907 )

• increased proliferation biliary epithelial cells but not of hepatocytes is seen starting at 2 weeks of age

increased hepatocyte apoptosis ( J:100907 )

• a slight increase in hepatocyte apoptosis is seen at 7 months of age

abnormal oval cell physiology ( J:100907 )

• increased proliferation of periportal oval cells but not of hepatocytes is seen starting at 2 weeks of age

• apoptosis of oval cells is also increased at early time points

cellular

increased hepatocyte apoptosis ( J:100907 )

• a slight increase in hepatocyte apoptosis is seen at 7 months of age