Phenotypes Associated with This Genotype

Genotype
MGI:3606960

• Allelic Composition: Tg(KRT14-HPV16E7)2304Plam/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin squamous cell carcinoma incidence ( J:86018 )

• beginning around 9 months of age, small highly keratotic lesions representing low-grade squamous cell carcinomas are seen in the skin

growth/size/body

epithelioid cyst ( J:86018 )

• beginning around 9 months of age, large, cystic but nonkeratotic lesions representing aggressive sebaceous epitheliomas and containing large accumulations of sebum are seen in the skin

vision/eye

developmental cataract ( J:86018 )

• small bilateral cataracts are seen at birth

digestive/alimentary system

abnormal esophageal squamous epithelium morphology ( J:86018 )

• the thickness of the nucleated layer is increased in squamous epithelia in the upper digestive tract

abnormal stomach non-glandular epithelium morphology ( J:86018 )

• squamous epithelia in the forestomach is highly invaginated

cellular

abnormal cell cycle checkpoint function ( J:101623 )

• after exposure to 5 Gy of ionizing radiation skin cells do not display normal cell cycle arrest

increased hair follicle apoptosis ( J:86018 )

• an increase in apoptotic cells is seen in hair follicles

integument

increased hair follicle apoptosis ( J:86018 )

• an increase in apoptotic cells is seen in hair follicles

epithelioid cyst ( J:86018 )

• beginning around 9 months of age, large, cystic but nonkeratotic lesions representing aggressive sebaceous epitheliomas and containing large accumulations of sebum are seen in the skin

sparse hair ( J:86018 )

• mice appear scruffy with less dense fur

matted coat ( J:86018 )

• the fur often appears greasy and matted

greasy coat ( J:86018 )

• the fur often appears greasy and matted

abnormal epidermal layer morphology ( J:86018 , J:101623 )

• about a 5-fold increase in apoptosis primarily in the stratum granulosum and these apoptotic cells occur in patches (J:86018)

• squamous epithelia in the skin is highly invaginated (J:86018)

• the pattern of differentiation in the epidermis is disrupted with expansion of the keratin 10- and filaggrin-positive layers (J:101623)

epidermal hyperplasia ( J:86018 )

• clearly seen in adult ears

• a disorganized pattern of proliferating cells is seen in the skin with many proliferating cells that are not in contact with the basement membrane present

• hyperproliferation of epithelial cells results in lateral and vertical expansion of the affected epithelium

wrinkled skin ( J:86018 )

• first seen at P3 in most mice

thick skin ( J:86018 )

• the skin on the ears and/or snout is thickened in neonatal and adult mice

increased skin squamous cell carcinoma incidence ( J:86018 )

• beginning around 9 months of age, small highly keratotic lesions representing low-grade squamous cell carcinomas are seen in the skin