About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3606654
Allelic
Composition
Csf2tm1Mlg/Csf2tm1Mlg
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2tm1Mlg mutation (1 available); any Csf2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• homozygotes obtained at the expected Mendelian frequencies are fertile and clinically healthy up to at least 1 year of age

hematopoietic system
N
• homozygotes exhibit normal steady-state hematopoiesis with normal numbers of peripheral blood cells, bone marrow progenitors, and tissue hematopoietic populations, including splenic dendritic cells
• notably, mutant marrow is able to reconstitute lethally irradiated mutant recipients
• mutant alveolar macrophages display aberrant morphology, including significant accumulation of surfactant lipids and proteins
• however, no significant reduction of alveolar macrophages is observed

immune system
• mutant alveolar macrophages display aberrant morphology, including significant accumulation of surfactant lipids and proteins
• however, no significant reduction of alveolar macrophages is observed
• homozygotes develop extensive pulmonary lymphoid hyperplasia around both airways and veins
• lymphoid hyperplasia is characterized by the presence of B220+, CD4+ and CD8+ cells, in the absence of a detectable underlying infection
• resistant to experimental autoimmune encephalomyelitis
• myelin oligodendrocyte glycoprotein immunized mice show reduced IL-2 and Interferon-gamma recall response
• Ly-6hi bone marrow precursor cells fail to expand in actively immunized mice as they do in controls

respiratory system
• lung lavage fluid obtained from homozygotes displays an 8-fold increase in total protein content, with significant accumulation of surfactant proteins SP-A and SP-B
• similarly, the bronchoalveolar lavage is significantly enriched in SP-A, -B, and -C as well as in nonreducing oligomers of SP-A
• however, no accumulation of mature SP-A or its precursor is detected within type II pneumocytes
• mutant alveolar macrophages display aberrant morphology, including significant accumulation of surfactant lipids and proteins
• however, no significant reduction of alveolar macrophages is observed
• by 2 months, all homozygotes exhibit early alveolar proteinosis, with amorphous, acellular, eosinophilic material scattered in alveolar spaces
• progressive surfactant lipid and protein accumulation, identified by the presence of tubular myelin and multilamellated structures, becomes widespread at >7 months


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory