Phenotypes Associated with This Genotype

Genotype
MGI:3606626

• Allelic Composition: Sele^tm1Alb/Sele^tm1Alb
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal spleen morphology ( J:101979 )

• increase in splenic thrombosis in contrast to controls following infection with S. pneumoniae

eye inflammation ( J:101979 )

• panophthalmitis observed in 8% of mice following infection with S. pneumoniae

increased susceptibility to bacterial infection ( J:101979 )

• severity and duration of morbidity higher than wild-type after infection with Streptococcus pneumoniae

• higher S. pneumoniae bacterial load than controls

• survival rate was 7% in contrast to 57% for wild-type

• decreased ability to clear bacteremia among survivors

behavior/neurological

abnormal pilomotor reflex ( J:101979 )

• observed following infection with S. pneumoniae

tremors ( J:101979 )

• observed following infection with S. pneumoniae

head tilt ( J:101979 )

• observed following infection with S. pneumoniae

decreased locomotor activity ( J:101979 )

• observed following infection with S. pneumoniae

spinning ( J:101979 )

• observed following infection with S. pneumoniae

growth/size/body

weight loss ( J:101979 )

• 48 hours post-infection with S. pneumoniae

vision/eye

eye inflammation ( J:101979 )

• panophthalmitis observed in 8% of mice following infection with S. pneumoniae

hematopoietic system

abnormal spleen morphology ( J:101979 )

• increase in splenic thrombosis in contrast to controls following infection with S. pneumoniae