About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3606112
Allelic
Composition
Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsd17b4tm1Baes mutation (0 available); any Hsd17b4 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 30% of most severely affected mice die between 2 and 12 days of age (J:62314)
• about 30% of most severely affected mice die between 2 and 12 days of age (J:62314)
• mice die before 6 months (J:201698)
• mice die before 6 months (J:201698)

reproductive system
• no germ cells present at 6-20 weeks old (J:108368)
• no germ cells present at 6-20 weeks old (J:108368)
• spermatogenesis severely compromised at 5 weeks of age (J:108368)
• some tubules continue to carry sperm at 5 weeks (J:108368)
• spermatogenesis severely compromised at 5 weeks of age (J:108368)
• some tubules continue to carry sperm at 5 weeks (J:108368)
• spermatids still present at 5 weeks of age (J:108368)
• become elongated at 7 weeks of age (J:108368)
• spermatids still present at 5 weeks of age (J:108368)
• become elongated at 7 weeks of age (J:108368)
(J:108368)
(J:108368)
• normal at 10 days an 3 weeks of age (J:108368)
• some lipid drops present (J:108368)
• lipid present on periphery of tubules at 5 weeks of age (J:108368)
• normal at 10 days an 3 weeks of age (J:108368)
• some lipid drops present (J:108368)
• lipid present on periphery of tubules at 5 weeks of age (J:108368)
• empty or filled with fibrous debris at 7 weeks (J:108368)
• multilayered structure of tubules lost (J:108368)
• only a few cell layers remaining by 12 and 16 weeks (J:108368)
• become severely atrophied at 6- 20 weeks of age (J:108368)
• lipid filled (J:108368)
• empty or filled with fibrous debris at 7 weeks (J:108368)
• multilayered structure of tubules lost (J:108368)
• only a few cell layers remaining by 12 and 16 weeks (J:108368)
• become severely atrophied at 6- 20 weeks of age (J:108368)
• lipid filled (J:108368)
• descend normally (J:108368)
• small size (J:108368)
• descend normally (J:108368)
• small size (J:108368)
• no sperm present (J:108368)
• no sperm present (J:108368)
• 6-20 week old males mate but fail to sire offspring (J:108368)
• 6-20 week old males mate but fail to sire offspring (J:108368)
• severely reduced fertility in males but not in females (J:62314)
• severely reduced fertility in males but not in females (J:62314)

nervous system
N
• no abnormalities are observed in cortical neuronal migration (J:104835)
• no abnormalities are observed in cortical neuronal migration (J:104835)
• severe with earliest onset between 1 and 2 months and increasing severity with age (J:201698)
• more prominent in gray matter in all brain regions except for the cerebellum (J:201698)
• in the anterior and posterior horns of the spinal cord but not in the white matter tracts (J:201698)
• severe with earliest onset between 1 and 2 months and increasing severity with age (J:201698)
• more prominent in gray matter in all brain regions except for the cerebellum (J:201698)
• in the anterior and posterior horns of the spinal cord but not in the white matter tracts (J:201698)
• at 4 months (J:201698)
• at 4 months (J:201698)
• loss of axonal integrity with swelling prior to demyelination (J:201698)
• loss of axonal integrity with swelling prior to demyelination (J:201698)

behavior/neurological
• anxious phenotype beyond 12 weeks (J:201698)
• anxious phenotype beyond 12 weeks (J:201698)
• beyond 12 weeks (J:201698)
• beyond 12 weeks (J:201698)
• severe beyond 12 weeks (J:201698)
• severe beyond 12 weeks (J:201698)
• on a rotarod from 4 weeks, worsening with age (J:201698)
• beyond 12 weeks of age, mice exhibit frequent falls (J:201698)
• on a rotarod from 4 weeks, worsening with age (J:201698)
• beyond 12 weeks of age, mice exhibit frequent falls (J:201698)
• mice become lethargic as their condition deteriorates between 4 and 6 months with hind paws often retracted to the body (J:201698)
• mice become lethargic as their condition deteriorates between 4 and 6 months with hind paws often retracted to the body (J:201698)
• unsteady gait beyond 12 weeks (J:201698)
• unsteady gait beyond 12 weeks (J:201698)

homeostasis/metabolism
• considerable decrease in oxidation of long chain fatty acids as well as branched chain fatty acids (J:104835)
• considerable decrease in oxidation of long chain fatty acids as well as branched chain fatty acids (J:104835)
• levels of C26 fatty acids increased 3-6X in livers and brains (J:62314)
• increased levels of branched fatty acids (J:62314)
• levels of C26 fatty acids increased 3-6X in livers and brains (J:62314)
• increased levels of branched fatty acids (J:62314)
• altered bile salt concentration (J:99925)
• altered bile salt concentration (J:99925)
• accumulation of long chain fatty acids in the cortex (J:201698)
• accumulation of long chain fatty acids in the cortex (J:201698)

digestive/alimentary system
• more undigested material in feces of suckling mice than for littermate controls (J:62314)
• more undigested material in feces of suckling mice than for littermate controls (J:62314)

growth/size/body
• body weight 50% lower than littermate controls at weaning (J:62314)
• body weight 50% lower than littermate controls at weaning (J:62314)
• noticeable from age 2 days onward (J:62314)
• growth improves after weaning but adults still are 30% lower in weight than controls (J:62314)
• noticeable from age 2 days onward (J:62314)
• growth improves after weaning but adults still are 30% lower in weight than controls (J:62314)

vision/eye

endocrine/exocrine glands
(J:108368)
(J:108368)
• normal at 10 days an 3 weeks of age (J:108368)
• some lipid drops present (J:108368)
• lipid present on periphery of tubules at 5 weeks of age (J:108368)
• normal at 10 days an 3 weeks of age (J:108368)
• some lipid drops present (J:108368)
• lipid present on periphery of tubules at 5 weeks of age (J:108368)
• empty or filled with fibrous debris at 7 weeks (J:108368)
• multilayered structure of tubules lost (J:108368)
• only a few cell layers remaining by 12 and 16 weeks (J:108368)
• become severely atrophied at 6- 20 weeks of age (J:108368)
• lipid filled (J:108368)
• empty or filled with fibrous debris at 7 weeks (J:108368)
• multilayered structure of tubules lost (J:108368)
• only a few cell layers remaining by 12 and 16 weeks (J:108368)
• become severely atrophied at 6- 20 weeks of age (J:108368)
• lipid filled (J:108368)
• descend normally (J:108368)
• small size (J:108368)
• descend normally (J:108368)
• small size (J:108368)

hematopoietic system
• severe with earliest onset between 1 and 2 months and increasing severity with age (J:201698)
• more prominent in gray matter in all brain regions except for the cerebellum (J:201698)
• in the anterior and posterior horns of the spinal cord but not in the white matter tracts (J:201698)
• severe with earliest onset between 1 and 2 months and increasing severity with age (J:201698)
• more prominent in gray matter in all brain regions except for the cerebellum (J:201698)
• in the anterior and posterior horns of the spinal cord but not in the white matter tracts (J:201698)

immune system
• severe with earliest onset between 1 and 2 months and increasing severity with age (J:201698)
• more prominent in gray matter in all brain regions except for the cerebellum (J:201698)
• in the anterior and posterior horns of the spinal cord but not in the white matter tracts (J:201698)
• severe with earliest onset between 1 and 2 months and increasing severity with age (J:201698)
• more prominent in gray matter in all brain regions except for the cerebellum (J:201698)
• in the anterior and posterior horns of the spinal cord but not in the white matter tracts (J:201698)

Mouse Models of Human Disease
OMIM ID Ref(s)
D-Bifunctional Protein Deficiency 261515 J:62314 , J:99925


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory