Phenotypes Associated with This Genotype

Genotype
MGI:3606111

• Allelic Composition: Tg(APP)6209Kha/0
• Genetic Background: FVB/N-Tg(APP)6209Kha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:43446 , J:29880 )

• Background Sensitivity: ~50% of mice die by 150 days of age; lethality begins to be observed at ~55 days (J:43446)

• 50% dead at 156 days of age (J:29880)

nervous system

abnormal astrocyte morphology ( J:29880 )

• hypertrophic astrocytes in the parahippocampal area, hippocampus, amygdala, and cerebral cortex

amyloid beta deposits ( J:43446 )

• levels are not significantly different from that observed on other backgrounds

homeostasis/metabolism

amyloidosis ( J:43446 )

amyloid beta deposits ( J:43446 )

• levels are not significantly different from that observed on other backgrounds

cellular

abnormal astrocyte morphology ( J:29880 )

• hypertrophic astrocytes in the parahippocampal area, hippocampus, amygdala, and cerebral cortex