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Phenotypes Associated with This Genotype
Genotype
MGI:3605834
Allelic
Composition
Tectatm2Gpr/Tecta+
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectatm2Gpr mutation (4 available); any Tecta mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• Hensen's stripe is absent
• limbal zone of tectorial membrane is extremely reduced, however hair bundle structure is normal
• enlargement of the subtectorial space in the vicinity of inner hair cell bundles
• Kimura's membrane is separated from the main body of the tectorial membrane
• large holes are visible within the main body of the matrix
• striated-sheet matrix is not present in the sulcal zone and collagen fibrils are oriented almost perpendicular to its surface rather than projecting radially across the tectorial membrane
• neural response thresholds are elevated, neural tuning is broadened, and a sharp decrease in sensitivity is observed at the tip of the neural tuning curve, however the sensitivity and frequency tuning of the mechanical responses of the cochlea are little changed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant nonsyndromic deafness 12 DOID:0110544 OMIM:601543
J:101691


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory