Phenotypes Associated with This Genotype

Genotype
MGI:3605149

• Allelic Composition: Il6^tm1Poli/Il6^tm1Poli
• Genetic Background: CAnNCrl.129S(Cg)-Il6^tm1Poli

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:96706 )

• male homozygotes display decreased sensitivity to the depressing effects of LPS and IL-1beta on sickness behavior, with attenuated social exploration, immobility and body weight loss relative to wild-type males

abnormal stationary movement ( J:96706 )

• in response to i.p. injection of IL-1beta (1.0 g/mouse) and LPS (2.5 g/mouse), male homozygotes exhibit a shorter duration of immobility relative to wild-type males

abnormal social investigation ( J:96706 )

• in response to i.p. injection of IL-1beta (1.0 g/mouse) and LPS (2.5 g/mouse), male homozygotes show an attenuated reduction in social interaction relative to wild-type males

• notably, i.c.v. administration of IL-1beta and LPS depresses social exploration only in wild-type mice, whereas mutants remain unaffected

growth/size/body

abnormal body weight ( J:96706 )

• in response to i.p. injection of IL-1beta (1.0 g/mouse) and LPS (2.5 g/mouse), male homozygotes show an attenuated body weight loss relative to wild-type males

neoplasm

decreased incidence of induced tumors ( J:42869 )

• in response to i.p. injection with pristane oil, homozygotes exhibit delayed and reduced ascite development, fail to display changes in the cellular content of ascitic fluids, and do not develop any clinically or histologically detectable plasmacytomas

• occasional mature plasma cells with atypical or anaplastic features are detected in the ascitic fluid and mesenteric tissues of some homozygotes, indicating initial plasma cell transformation

immune system

abnormal immune system physiology ( J:96706 )

• 8- to 10-week-old male homozygotes are less affected by peripheral and central injections of IL-1beta and LPS than wild-type male littermates

abnormal B cell proliferation ( J:42869 )

• pristane-treated homozygotes exhibit a reduced frequency of B cell differentiation and plasma cell formation, with rare morphological signs of activation and scant B-cell blast aggregates

decreased inflammatory response ( J:42869 )

• in response to i.p. injection with pristane oil, homozygotes show an attenuated inflammatory response, with reduced peritoneal granuloma formation, reduced histiocyte and fibroblast number in granulomatous tissue, and only rare signs of B cell activation

hematopoietic system

abnormal B cell proliferation ( J:42869 )

• pristane-treated homozygotes exhibit a reduced frequency of B cell differentiation and plasma cell formation, with rare morphological signs of activation and scant B-cell blast aggregates

cellular

abnormal B cell proliferation ( J:42869 )

• pristane-treated homozygotes exhibit a reduced frequency of B cell differentiation and plasma cell formation, with rare morphological signs of activation and scant B-cell blast aggregates