Phenotypes Associated with This Genotype

Genotype
MGI:3604383

• Allelic Composition: Wnt3a^vt/Wnt3a^vt
• Genetic Background: involves: A * A/Gr * C57BR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal tail morphology ( J:14984 )

• at E9.5, the unsegmented mesoderm of the tail tip often appears more loosely knit

abnormal tail bud morphology ( J:14984 )

• more neural tissue is seen in the tail beginning at E11

decreased ventral ectodermal ridge size ( J:14984 )

• a reduction is seen in the ventral ectodermal ridge of the tail

vestigial tail ( J:14984 )

• decreased tail size can be distinguished at E11

embryo

abnormal neural tube morphology ( J:14984 )

• at E10 the ventral aspect of the neural tube separates from the rest by a capillary cleft and at E11 in some embryos multiple structures resembling neural tubes are seen surrounding a central blood vessel

abnormal tail bud morphology ( J:14984 )

• more neural tissue is seen in the tail beginning at E11

decreased ventral ectodermal ridge size ( J:14984 )

• a reduction is seen in the ventral ectodermal ridge of the tail

nervous system

abnormal neural tube morphology ( J:14984 )

• at E10 the ventral aspect of the neural tube separates from the rest by a capillary cleft and at E11 in some embryos multiple structures resembling neural tubes are seen surrounding a central blood vessel

digestive/alimentary system

abnormal tailgut morphology ( J:14984 )

• the tail gut (a diverticulum of the cloaca) does not extend as deeply into the tail in homozygotes