Phenotypes Associated with This Genotype

Genotype
MGI:3604354

• Allelic Composition: \Il11ra1^tm1Gos/\Il11ra1^tm1Gos
• Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal uterine NK cell morphology ( J:93811 )

♀ • on E7.5, the mesometrial decidual compartment is almost devoid of perforin-positive NK cells, despite normal uterine NK precursor cell homing

♀ • notably, in vitro, mutant splenic NK precursor cells show a normal response to IL-15

abnormal decidualization ( J:93811 )

♀ • on E7.5, the number of antimesometrial decidual cells expressing markers of decidual cell differentiation are reduced

♀ • on E7.5, homozygotes exhibit smaller implantation sites with disorganized vascular patterns

female infertility ( J:93811 )

♀ • female homozygotes are infertile as a result of decidual defects

embryo

decreased trophoblast giant cell number ( J:93811 )

• female homozygotes show altered distribution and reduced numbers of trophoblast cells at the implantation sites

abnormal uterine NK cell morphology ( J:93811 )

♀ • on E7.5, the mesometrial decidual compartment is almost devoid of perforin-positive NK cells, despite normal uterine NK precursor cell homing

♀ • notably, in vitro, mutant splenic NK precursor cells show a normal response to IL-15

abnormal placenta development ( J:93811 )

• female homozygotes exhibit defects in early placental development

abnormal decidualization ( J:93811 )

♀ • on E7.5, the number of antimesometrial decidual cells expressing markers of decidual cell differentiation are reduced

♀ • on E7.5, homozygotes exhibit smaller implantation sites with disorganized vascular patterns

hematopoietic system

abnormal uterine NK cell morphology ( J:93811 )

♀ • on E7.5, the mesometrial decidual compartment is almost devoid of perforin-positive NK cells, despite normal uterine NK precursor cell homing

♀ • notably, in vitro, mutant splenic NK precursor cells show a normal response to IL-15

abnormal NK cell differentiation ( J:93811 )

• female homozygotes show abnormal decidual-specific differentiation of NK cells at the maternal-fetal interface

cardiovascular system

abnormal vascular development ( J:93811 )

• on E7.5, female homozygotes display disorganized decidual vascularization at the implantation sites

immune system

abnormal uterine NK cell morphology ( J:93811 )

♀ • on E7.5, the mesometrial decidual compartment is almost devoid of perforin-positive NK cells, despite normal uterine NK precursor cell homing

♀ • notably, in vitro, mutant splenic NK precursor cells show a normal response to IL-15

abnormal NK cell differentiation ( J:93811 )

• female homozygotes show abnormal decidual-specific differentiation of NK cells at the maternal-fetal interface

endocrine/exocrine glands

abnormal uterine NK cell morphology ( J:93811 )

♀ • on E7.5, the mesometrial decidual compartment is almost devoid of perforin-positive NK cells, despite normal uterine NK precursor cell homing

♀ • notably, in vitro, mutant splenic NK precursor cells show a normal response to IL-15