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Phenotypes Associated with This Genotype
Genotype
MGI:3604113
Allelic
Composition
Csf2rbtm1Mur/Csf2rbtm1Mur
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2rbtm1Mur mutation (0 available); any Csf2rb mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the number of eosinophils in the peripheral blood is reduced
• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, response to bacterial infection and hematopoietic cell recovery after treatment with a cytotoxic agent are normal
• peribronchovascular lymphocytic infiltration

respiratory system
• peribronchovascular lymphocytic infiltration
• a focal but scattered intraalveolar proteinacious substance is seen associated with expanded foamy pulmonary alveolar macrophages

hematopoietic system
• no colonies are formed in vitro in the presence of granulocyte-macrophage colony-stimulating factor or IL-5
• the number of eosinophils in the peripheral blood is reduced
• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, response to bacterial infection and hematopoietic cell recovery after treatment with a cytotoxic agent are normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory