Phenotypes Associated with This Genotype

Genotype
MGI:3603924

• Allelic Composition: Pax1^un-i/Pax1⁺
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte number ( J:100951 )

• at E17.5, E19.5 and 6 weeks of age, thymocyte numbers are significantly reduced compared to wild-type mice but increased compared to homozygous mutants

decreased CD4-positive, alpha-beta T cell number ( J:100951 )

• the number of CD4+ cells is decreased at 6 weeks of age compared to wild-type mice but increased compared to homozygous mutants

decreased CD8-positive, alpha-beta T cell number ( J:100951 )

• the number of CD8+ cells is decreased at 6 weeks of age compared to wild-type mice but increased compared to homozygous mutants

hematopoietic system

decreased thymocyte number ( J:100951 )

• at E17.5, E19.5 and 6 weeks of age, thymocyte numbers are significantly reduced compared to wild-type mice but increased compared to homozygous mutants

decreased CD4-positive, alpha-beta T cell number ( J:100951 )

• the number of CD4+ cells is decreased at 6 weeks of age compared to wild-type mice but increased compared to homozygous mutants

decreased CD8-positive, alpha-beta T cell number ( J:100951 )

• the number of CD8+ cells is decreased at 6 weeks of age compared to wild-type mice but increased compared to homozygous mutants

endocrine/exocrine glands

decreased thymocyte number ( J:100951 )

• at E17.5, E19.5 and 6 weeks of age, thymocyte numbers are significantly reduced compared to wild-type mice but increased compared to homozygous mutants