Mouse Genome Informatics
hm
    Ifngr2tm1Pbro/Ifngr2tm1Pbro
NOD.129S1-Ifngr2tm1Pbro
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• enhanced Th2 responses
• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis
• when diabetogenic splenocytes are injected into Ifngr2-deficient NOD mice, diabetes development is delayed compared to wild-type NOD mice

homeostasis/metabolism
N
• unexpectedly, incidence of type 1 diabetes in females was unchanged (J:65986)

hematopoietic system
• enhanced Th2 responses
• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:72818