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Phenotypes Associated with This Genotype
Genotype
MGI:3603845
Allelic
Composition
Ifngr2tm1Pbro/Ifngr2tm1Pbro
Genetic
Background
NOD.129S1-Ifngr2tm1Pbro
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr2tm1Pbro mutation (2 available); any Ifngr2 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• enhanced Th2 responses
• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis
• when diabetogenic splenocytes are injected into Ifngr2-deficient NOD mice, diabetes development is delayed compared to wild-type NOD mice

homeostasis/metabolism
N
• unexpectedly, incidence of type 1 diabetes in females was unchanged

hematopoietic system
• enhanced Th2 responses
• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:72818


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory