Phenotypes Associated with This Genotype

Genotype
MGI:3603831

• Allelic Composition: Ptgs2^tm1Unc/Ptgs2^tm1Unc
• Genetic Background: D1.129P2(B6J)-Ptgs2^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:64383 )

N • Background Sensitivity: adult homozygotes do not exhibit reduced longevity, unlike homozygotes generated on a predominantly C57BL/6J background

postnatal lethality ( J:102777 )

• only 66% of homozygotes survive to weaning versus 92% of wild-type controls; however, no adult mice are found to die spontaneously during a 6-month study period

• Background Sensitivity: adult homozygotes do not die from renal failure, unlike homozygotes generated on a predominantly C57BL/6 background

renal/urinary system

abnormal kidney morphology ( J:64383 )

• Background Sensitivity: adult homozygotes do not exhibit the severe renal pathology observed in homozygotes of a predominantly C57BL/6J genetic background

renal glomerulus cyst ( J:102777 )

• by 9 months of age, small subcapsular glomeruli are detected in cystic spaces

• Background Sensitivity: cystic changes are less severe than those observed on a predominantly C57BL/6 background

abnormal renal glomerulus morphology ( J:102777 )

• hypoplastic subcapsular glomeruli are observed by P14 and become cystic as mice age, unlike in wild-type controls

renal glomerulus hypertrophy ( J:102777 )

• inner cortical hyperplastic glomeruli are seen at 3 weeks of age, unlike in wild-type controls

abnormal kidney mesenchyme morphology ( J:102777 )

• undifferentiated mesenchyme is seen as early as P7, unlike in wild-type controls

renal interstitial fibrosis ( J:102777 )

• interstitial fibrosis is noted at 3 weeks and becomes prominent by 8 months of age

small kidney ( J:102777 )

• mutant kidneys are smaller than wild-type

decreased kidney weight ( J:102777 )

• at 34 weeks of age, the ratio of kidney weight to total body weight is significantly lower than that of wild-type controls

granular kidney ( J:102777 )

• mutant kidneys have a more granular surface than wild-type

pale kidney ( J:102777 )

• mutant kidneys appear paler than wild-type

reproductive system

female infertility ( J:64383 )

♀ • female homozygous mutant mice are infertile

homeostasis/metabolism

increased circulating creatinine level ( J:102777 )

• at 10, 16, 20 and 28 weeks of age, average plasma creatinine levels are significantly higher than in wild-type controls

increased blood urea nitrogen level ( J:102777 )

• at 2-8 months of age, homozygotes show a ~2-fold increase in BUN levels relative to wild-type controls

• Background Sensitivity: increase in BUN levels is significantly lower than that reported for homozygotes on a B6 genetic background (200% versus 270%)

hematopoietic system

decreased hematocrit ( J:102777 )

• hematocrit values are significantly lower than those of wild type controls at most time points during a 6-month study period

behavior/neurological

behavior/neurological phenotype ( J:64383 )

N • both male and female homozygotes display normal reaction times in the hot plate test, indicating normal thermal nociception

decreased aggression ( J:64383 )

• homozygotes appear to be less excitable and easier to handle than wild-type littermates

• docile behavior is most evident in female homozygotes

growth/size/body

renal glomerulus cyst ( J:102777 )

• by 9 months of age, small subcapsular glomeruli are detected in cystic spaces

• Background Sensitivity: cystic changes are less severe than those observed on a predominantly C57BL/6 background