Phenotypes Associated with This Genotype

Genotype
MGI:3603829

• Allelic Composition: Rrn3^tm1.2Igt/Rrn3^tm1.2Igt
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:99711 )

• embryos die around E9.5

embryo

incomplete embryo turning ( J:99711 )

• embryos are unturned at E9.5

embryonic growth retardation ( J:99711 )

• at E9.5 structures and organs appear reduced in number or smaller and developmentally retarded

decreased embryo size ( J:99711 )

• at E9.5 embryos are about 10- 20-fold smaller than wild-type littermates; however all 3 germ layers are present

abnormal neural tube morphology ( J:99711 )

• at E9.5 the neural tube is small and appears developmentally retarded

incomplete somite formation ( J:99711 )

• at E9.5 fewer somites are present, similar in number to wild-type somites at E7.5

nervous system

increased neural tube apoptosis ( J:99711 )

• at E9.5, 25% of the cells in the neural tube are apoptotic and overall apoptosis is strongly enhanced; however cell size is normal

abnormal neural tube morphology ( J:99711 )

• at E9.5 the neural tube is small and appears developmentally retarded

growth/size/body

embryonic growth retardation ( J:99711 )

• at E9.5 structures and organs appear reduced in number or smaller and developmentally retarded

decreased embryo size ( J:99711 )

• at E9.5 embryos are about 10- 20-fold smaller than wild-type littermates; however all 3 germ layers are present

cellular

increased neural tube apoptosis ( J:99711 )

• at E9.5, 25% of the cells in the neural tube are apoptotic and overall apoptosis is strongly enhanced; however cell size is normal