About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3603799
Allelic
Composition
Igbp1tm1Imku/Y
Tg(Lck-cre)I57Jxm/?
Genetic
Background
involves: 129P2/OlaHsd * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igbp1tm1Imku mutation (0 available); any Igbp1 mutation (10 available)
Tg(Lck-cre)I57Jxm mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• largely lacking in double positive cells
• demarcation between cortex and medulla indistinct
• peripheral spleen T cells 30% of control levels
• thymocyte production only 4.3% normal
• few proliferating thymocytes
• double negative cells are proportionately higher but absolute numbers are reduced
• development blocked at DN3 stage

hematopoietic system
• largely lacking in double positive cells
• demarcation between cortex and medulla indistinct
• peripheral spleen T cells 30% of control levels
• thymocyte production only 4.3% normal
• few proliferating thymocytes
• double negative cells are proportionately higher but absolute numbers are reduced
• development blocked at DN3 stage

endocrine/exocrine glands
• largely lacking in double positive cells
• demarcation between cortex and medulla indistinct
• thymocyte production only 4.3% normal
• few proliferating thymocytes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
01/28/2026
MGI 6.24
The Jackson Laboratory