Phenotypes Associated with This Genotype

Genotype
MGI:3603650

• Allelic Composition: Igf1^tm1Dlr/Igf1^tm1Dlr; Igfals^tm1Yrb/Igfals^tm1Yrb; Tg(Alb1-cre)1Dlr/?
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/? mice exhibit reduced growth plate height

growth/size/body

decreased body length ( J:79109 )

• 30% reduction in total length by 2-3 weeks of age

skeleton

abnormal limb bone morphology ( J:79109 )

abnormal femur morphology ( J:79109 )

• reduced cortical bone thickness

• reduced trabecular bone volume and trabecular bone density

decreased diameter of femur ( J:79109 )

short femur ( J:79109 )

• 20% shorter at 21 days of age and 12% shorter at 6 weeks of age

abnormal long bone epiphyseal plate proliferative zone ( J:79109 )

• reduced 15 %

decreased width of hypertrophic chondrocyte zone ( J:79109 )

• reduced 26%

decreased long bone epiphyseal plate size ( J:79109 )

• tibial growth plate height reduced by 20%

• germinal zone height increased in the tibia

limbs/digits/tail

abnormal limb bone morphology ( J:79109 )

abnormal femur morphology ( J:79109 )

• reduced cortical bone thickness

• reduced trabecular bone volume and trabecular bone density

decreased diameter of femur ( J:79109 )

short femur ( J:79109 )

• 20% shorter at 21 days of age and 12% shorter at 6 weeks of age