Phenotypes for Casp3 Casp6 MGI:3603541 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Casp3^tm1Flv/Casp3^tm1Flv Casp6^tm1Flv/Casp6^tm1Flv
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp3^tm1Flv mutation (1 available); any Casp3 mutation (32 available)
Casp6^tm1Flv mutation (1 available); any Casp6 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:101037 )

• slightly smaller than normal

vision/eye

vision/eye phenotype ( J:101037 )

N	• normal tissue organization in the equatorial lens and normal denucleation process in lens

anterior polar cataract ( J:101037 )

• anterior polar cataracts are more pronounced than in mice disrupted for only caspase 3

microphthalmia ( J:101037 )

• incomplete penetrence, occurs in less than half the mice

anophthalmia ( J:101037 )

• incomplete penetrence

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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