Phenotypes Associated with This Genotype

Genotype
MGI:3603538

• Allelic Composition: Casp6^tm1Flv/Casp6^tm1Flv
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:101037 )

N • no change in the distance between the equatorial surface of the lens and the border of the organelle free zone

N • lenses appear grossly normal

N • lens extracts display normal levels of lysis of fluorogenic substrate VEID-AMC

abnormal lens development ( J:101037 )

• staurosporine treatment of lenses fails to induce increased lysis of fluorogenic substrate VEID-AMC as it does in wild-type lenses

cellular

cellular phenotype ( J:59875 )

N • normal phosphatidyl serine flip-flop in thymocytes treated with dexamethasone