Phenotypes Associated with This Genotype

Genotype
MGI:3603516

• Allelic Composition: Ighmbp2^nmd-2J/Ighmbp2^nmd-2J; Mnm^C/Mnm^C
• Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:51890 , J:90418 )

• Background Sensitivity: survival to as long as 7 months of age, but less as the B6 component of the background increases (J:51890)

cardiovascular system

abnormal cardiovascular system physiology ( J:90418 )

dilated cardiomyopathy ( J:90418 )

• grossly dilated hearts with one or more thrombi

abnormal impulse conducting system conduction ( J:90418 )

prolonged PR interval ( J:90418 )

• prolonged P-R interval

prolonged P wave ( J:90418 )

• sometimes split

prolonged QRS complex duration ( J:90418 )

nervous system

abnormal innervation pattern to muscle ( J:51890 )

• fewer dying neurons

motor neuron degeneration ( J:90418 )

• modest reduction in lumbar ventral root diameter

• 26% of L4 motor axons lost

• occasional dystrophic axons in ventral roots

• 25% loss of small caliber axons

behavior/neurological

decreased grip strength ( J:90418 )

• shorter latence to fall when suspended from a wire cage top

muscle

dilated cardiomyopathy ( J:90418 )

• grossly dilated hearts with one or more thrombi

muscle degeneration ( J:90418 )

• moderate myopathic changes

muscular atrophy ( J:51890 )

• milder muscle atrophy

respiratory system

pulmonary edema ( J:90418 )

• consolidation of lungs

pleural effusion ( J:90418 )

decreased pulmonary respiratory rate ( J:90418 )

• reduced breathing rate (bradypnea)

growth/size/body

weight loss ( J:90418 )

homeostasis/metabolism

increased circulating creatine kinase level ( J:90418 )

• 3-7 days prior to clearly evident clinical signs of heart disease, total plasma CK and cardiac-specific CK-MB levels in 5- to 9-week-old mice become significantly elevated

pulmonary edema ( J:90418 )

• consolidation of lungs

pleural effusion ( J:90418 )