Phenotypes Associated with This Genotype

Genotype
MGI:3603467

• Allelic Composition: Ighmbp2^nmd-2J/Ighmbp2^nmd-2J
• Genetic Background: BKS.Cg Dock7^m +/+ Lepr^db-Ighmbp2^nmd-2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:23584 )

• death usually by 3.5 weeks although survival for several months is possible if left with parents without normal siblings present

behavior/neurological

limb grasping ( J:23584 )

• clench hindlimbs when picked up by the tail

abnormal grip strength ( J:23584 )

• unable to grasp cage cover when set upon it

abnormal gait ( J:23584 )

• rely on forelimbs to crawl forward, but balance and righting responses are normal

hindlimb paralysis ( J:23584 )

• dorsally contracted hindlimbs cannot be extended to stand erect or assume full posture on four limbs

muscle

abnormal masseter muscle morphology ( J:23584 )

• atrophic muscle fibers in the masseter

abnormal temporalis muscle morphology ( J:23584 )

• atrophic muscle fibers in the temporalis muscle

abnormal skeletal muscle fiber morphology ( J:23584 )

• intermixture of very small muscle fibers with more normal fibers

• distal musculature of limbs more severely affected but focal areas of muscle degeneration proximally as well

nervous system

abnormal innervation pattern to muscle ( J:23584 )

• affected alpha motor neurons with pale staining nuclei and perikarya

• mostly in lumbar region

craniofacial

abnormal masseter muscle morphology ( J:23584 )

• atrophic muscle fibers in the masseter

abnormal temporalis muscle morphology ( J:23584 )

• atrophic muscle fibers in the temporalis muscle

growth/size/body

abnormal masseter muscle morphology ( J:23584 )

• atrophic muscle fibers in the masseter

abnormal temporalis muscle morphology ( J:23584 )

• atrophic muscle fibers in the temporalis muscle