Phenotypes Associated with This Genotype

Genotype
MGI:3603436

• Allelic Composition: Gcnt2^tm1Tmu/Gcnt2^tm1Tmu
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased locomotor activity ( J:100533 )

• significantly reduced spontaneous activity recorded by a computerized activity-tracing chamber

• no motor coordination abnormality were found on rota-rod testing

hematopoietic system

decreased B cell number ( J:100533 )

• decrease in the number of lymphocytes caused by the decrease in the number of B cells in both the 2-month-old and the 6-month-old mutant mice

immune system

decreased B cell number ( J:100533 )

• decrease in the number of lymphocytes caused by the decrease in the number of B cells in both the 2-month-old and the 6-month-old mutant mice

homeostasis/metabolism

increased circulating creatinine level ( J:100533 )

increased blood urea nitrogen level ( J:100533 )

renal/urinary system

abnormal renal tubule epithelium morphology ( J:100533 )

• vacuolization in tubular epithelial cells of 8-mont-old mutant mice

integument

epithelioid cyst ( J:100533 )

• male mutant mice frequently developed epidermoid cysts in the abdominal skin

• until 8 months after birth, the incidence of epidermoid cysts increased to 50%

growth/size/body

epithelioid cyst ( J:100533 )

• male mutant mice frequently developed epidermoid cysts in the abdominal skin

• until 8 months after birth, the incidence of epidermoid cysts increased to 50%