About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3603361
Allelic
Composition		 Ptgirtm1Sna/Ptgirtm1Sna
Tbxa2rtm1Cof/Tbxa2rtm1Cof
Genetic
Background		 129-Ptgirtm1Sna Tbxa2rtm1Cof
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgirtm1Sna mutation (1 available); any Ptgir mutation (31 available)
Tbxa2rtm1Cof mutation (0 available); any Tbxa2r mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:79049 )
N
• following catheter-induced carotid vascular injury, double homozygotes fail to exhibit the enhanced vascular proliferative response observed in Ptgirtm1Sna homozygotes
• in double homozygotes, the intima-to-media ratio, % of luminal stenosis, and the number of BrdU-labeled cells is comparable to observed in wild-type mice; in addition, the periprocedural increment in platelet activation noted in Ptgirtm1Sna homozygotes is abolished

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory