Mouse Genome Informatics
hm
    Spred2Gt(XB228)Byg/Spred2Gt(XB228)Byg
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Achondroplasia-like dwarfism in Spred2Gt(XB228)Byg/Spred2Gt(XB228)Byg mice

growth/size
• smaller at birth and stay small throughout life, however levels of testosterone, estrogen, thyroid stimulating hormone, and thyroxin are normal
• more pronounced in males than females, although seen in both

reproductive system
• average litter size is 4.4 pups compared to 8.4 pups in wild-type

hematopoietic system
• increase in number of megakaryocytes in the spleen

skeleton

limbs/digits/tail

Mouse Models of Human Disease
OMIM IDRef(s)
Achondroplasia; ACH 100800 J:100826