Mouse Genome Informatics
cn
    Gcktm1.1Mgn/Gck+
Tg(Ins2-cre)25Mgn/0

involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• 70% decrease in insulin secretion during hyperglycemic clamp studies
• blood glucose concentration is increased by about 50% compared to heterozygous Gcktm1.1Mgn mice
• under fasting conditions, have a 25% increase in blood glucose concentration, without differences in basal insulin concentration
• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced by about 60 and 70%, respectively
• net glycogen synthesis in liver is reduced by about 50% during hyperglycemic clamp studies

endocrine/exocrine glands
• 70% decrease in insulin secretion during hyperglycemic clamp studies

Mouse Models of Human Disease
OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826