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Phenotypes Associated with This Genotype
Genotype
MGI:3603003
Allelic
Composition
Gcktm1.1Mgn/Gcktm1.1Mgn
Tg(Ins2-cre)25Mgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1.1Mgn mutation (1 available); any Gck mutation (35 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• more than 80% neonatal mortality as a result of severe hyperglycemia

homeostasis/metabolism
• highly variable but increased blood glucose concentrations
• decreased by about 70%
• diminished hepatic glycogen

liver/biliary system

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory