Mouse Genome Informatics
ht
    Gcktm1.2Mgn/Gck+
involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• insulin secretion in response to the hyperglycemic clamp is decreased by 60%
• plasma glucose concentration increases over time (117 mg/dl vs. 73 mg/dl in wild-type at 2 days and 304 mg/dl vs. 175 mg/dl in wild-type at 6-10 weeks of age)
• 70% reduction in glucose infusion rate in hyperglycemic clamp studies
• intermediate levels of hepatic glycogen under normal conditions
• hepatic glycogen synthesis is decreased by more than 90% in response to the hyperglycemic clamp

liver/biliary system
• intermediate amount of steatosis

endocrine/exocrine glands
• insulin secretion in response to the hyperglycemic clamp is decreased by 60%

Mouse Models of Human Disease
OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826