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Phenotypes Associated with This Genotype
Genotype
MGI:3590686
Allelic
Composition
Gcktm1.2Mgn/Gck+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1.2Mgn mutation (0 available); any Gck mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• insulin secretion in response to the hyperglycemic clamp is decreased by 60%
• plasma glucose concentration increases over time (117 mg/dl vs. 73 mg/dl in wild-type at 2 days and 304 mg/dl vs. 175 mg/dl in wild-type at 6-10 weeks of age)
• 70% reduction in glucose infusion rate in hyperglycemic clamp studies
• intermediate levels of hepatic glycogen under normal conditions
• hepatic glycogen synthesis is decreased by more than 90% in response to the hyperglycemic clamp

liver/biliary system
• intermediate amount of steatosis

endocrine/exocrine glands
• insulin secretion in response to the hyperglycemic clamp is decreased by 60%

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
maturity-onset diabetes of the young type 2 DOID:0111100 OMIM:125851
J:51826


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/28/2017
MGI 6.11
The Jackson Laboratory