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Phenotypes Associated with This Genotype
Genotype
MGI:3590685
Allelic
Composition
Gcktm1.2Mgn/Gcktm1.2Mgn
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1.2Mgn mutation (0 available); any Gck mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 4 days of birth from severe diabetes (J:51826)
• die within 4 days of birth from severe diabetes (J:51826)

homeostasis/metabolism
• plasma glucose concentration of 566 mg/dl compared to 73 mg/dl in wild-type, at 2 days of age (J:51826)
• plasma glucose concentration of 566 mg/dl compared to 73 mg/dl in wild-type, at 2 days of age (J:51826)
• reduced by approximately 70% (J:51826)
• reduced by approximately 70% (J:51826)
• about 1.8-fold increase (J:51826)
• about 1.8-fold increase (J:51826)
• diminished hepatic glycogen (J:51826)
• diminished hepatic glycogen (J:51826)

liver/biliary system

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory