Phenotypes Associated with This Genotype

Genotype
MGI:3590551

• Allelic Composition: Phc1^tm1Os/Phc1⁺; Phc2^tm1Hko/Phc2^tm1Hko
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:100027 )

• mutants are alive at E17.5 but do not survive birth

skeleton

abnormal skeleton morphology ( J:100027 )

• skeletal defects are more severe than in mice homozygous for Phc2 only

abnormal occipital bone morphology ( J:100027 )

• the dorsal part of the occipital bone is floating

scapular bone foramen ( J:100027 )

• there is a hole in the scapula

abnormal sternocostal joint morphology ( J:100027 )

• the 6th ribs are detached from the sternum

abnormal cervical vertebrae morphology ( J:100027 )

• anterior processes are associated with the 5th cervical vertebra (C5)

craniofacial

abnormal occipital bone morphology ( J:100027 )

• the dorsal part of the occipital bone is floating

cleft secondary palate ( J:100027 )

digestive/alimentary system

cleft secondary palate ( J:100027 )

growth/size/body

cleft secondary palate ( J:100027 )