Phenotypes Associated with This Genotype

Genotype
MGI:3590313

• Allelic Composition: Ralbp1^{Gt(OST359995)Lex}/Ralbp1⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:100087 )

• survival after X-ray exposure is significantly shorter for homozygotes compared to wild-type mice

cellular

oxidative stress ( J:100087 )

• markers of oxidative stress are increased, activities of GSH-linked antioxidant enzymes are decreased, and levels of GSH are increased

• changes are greater in homozygotes than in heterozygotes and changes are greater in males than in females