Phenotypes Associated with This Genotype

Genotype
MGI:3590200

• Allelic Composition: Ccdc62^repro29/Ccdc62^repro29
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:244081 )

N • males show normal testes appearance, size and weight as well as normal sperm count

N • females show normal fertility with no alteration in litter size

oligozoospermia ( J:92463 )

♂ • low epididymal sperm concentration

teratozoospermia ( J:92463 , J:244081 )

♂ • abnormally shaped sperm heads with and without tails (J:92463)

♂ • virtually all sperm malformed (J:244081)

abnormal sperm midpiece morphology ( J:244081 )

♂ • enclosed within a cytoplasm bag

♂ • wrapped around head

abnormal sperm head morphology ( J:244081 )

♂ • flagellum midpiece wrapped around head

♂ • enclosed within a cytoplasm bag

absent acrosome ( J:244081 )

♂

asthenozoospermia ( J:92463 , J:244081 )

♂ • very low sperm motility (J:92463)

♂ • motility of cauda epididymal sperm reduced to 5% of wild-type (J:244081)

decreased seminal vesicle weight ( J:92463 )

♂ • low seminal vesicle weight

abnormal spermiogenesis ( J:92463 )

♂ • abnormal spermatid head shape and low number of elongating spermatids

male infertility ( J:92463 , J:244081 )

♂ • males are infertile and in vitro fertilization has very low success (J:92463)

♂ • male infertility observed after 2 months mating with wild-type or heterozygous mutant females (J:244081)

cellular

oligozoospermia ( J:92463 )

♂ • low epididymal sperm concentration

teratozoospermia ( J:92463 , J:244081 )

♂ • abnormally shaped sperm heads with and without tails (J:92463)

♂ • virtually all sperm malformed (J:244081)

abnormal sperm midpiece morphology ( J:244081 )

♂ • enclosed within a cytoplasm bag

♂ • wrapped around head

abnormal sperm head morphology ( J:244081 )

♂ • flagellum midpiece wrapped around head

♂ • enclosed within a cytoplasm bag

absent acrosome ( J:244081 )

♂

asthenozoospermia ( J:92463 , J:244081 )

♂ • very low sperm motility (J:92463)

♂ • motility of cauda epididymal sperm reduced to 5% of wild-type (J:244081)

endocrine/exocrine glands

decreased seminal vesicle weight ( J:92463 )

♂ • low seminal vesicle weight