Phenotypes Associated with This Genotype

Genotype
MGI:3590176

• Allelic Composition: Hus1^tm1Led/Hus1^tm1Led
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

increased embryonic tissue cell apoptosis ( J:99339 )

• increased numbers of apoptotic cells are seen in embryonic and extraembryonic tissues at E7.0 - E8.5; however, cell proliferation appears normal

abnormal developmental patterning ( J:99339 )

• the uniformity and symmetry seen in wild-type embryos is absent

embryonic growth retardation ( J:99339 )

• delayed development is seen in some embryos at E8.0

decreased embryo size ( J:99339 )

• embryos are slightly smaller than wild-type littermates at E7.5 and severely reduced in size by E8.5

abnormal neural tube morphology ( J:99339 )

• at E8.5 cell debris is seen in the neural tube

cellular

increased embryonic tissue cell apoptosis ( J:99339 )

• increased numbers of apoptotic cells are seen in embryonic and extraembryonic tissues at E7.0 - E8.5; however, cell proliferation appears normal

nervous system

abnormal neural tube morphology ( J:99339 )

• at E8.5 cell debris is seen in the neural tube

growth/size/body

embryonic growth retardation ( J:99339 )

• delayed development is seen in some embryos at E8.0

decreased embryo size ( J:99339 )

• embryos are slightly smaller than wild-type littermates at E7.5 and severely reduced in size by E8.5