Phenotypes Associated with This Genotype

Genotype
MGI:3590081

• Allelic Composition: Cflar^tm1Ywh/Cflar^tm1Ywh; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased thymocyte apoptosis ( J:100558 )

• thymocytes from mutant mice shows enhanced apoptosis to TCR/CD3 and Fas stimulation

• without stimulation, three- to fourfold increases of apoptotic cells in freshly isolated CD4+ and CD8+ single-positive thymocytes over the control cells (there was no such increase for mutant double-positive cells)

decreased single-positive T cell number ( J:100558 )

• total thymocyte numbers were not significantly different from wild-type

• in 3-5 weeks old mice the percentages of CD4+ and CD8+ single-positive thymocytes were reduced by 50-70%

• the numbers of CD4+ and CD8+ T lymphocytes in peripheral blood, spleen and lymph nodes were significantly reduced

immune system

increased thymocyte apoptosis ( J:100558 )

• thymocytes from mutant mice shows enhanced apoptosis to TCR/CD3 and Fas stimulation

• without stimulation, three- to fourfold increases of apoptotic cells in freshly isolated CD4+ and CD8+ single-positive thymocytes over the control cells (there was no such increase for mutant double-positive cells)

decreased single-positive T cell number ( J:100558 )

• total thymocyte numbers were not significantly different from wild-type

• in 3-5 weeks old mice the percentages of CD4+ and CD8+ single-positive thymocytes were reduced by 50-70%

• the numbers of CD4+ and CD8+ T lymphocytes in peripheral blood, spleen and lymph nodes were significantly reduced

cellular

increased thymocyte apoptosis ( J:100558 )

• thymocytes from mutant mice shows enhanced apoptosis to TCR/CD3 and Fas stimulation

• without stimulation, three- to fourfold increases of apoptotic cells in freshly isolated CD4+ and CD8+ single-positive thymocytes over the control cells (there was no such increase for mutant double-positive cells)

endocrine/exocrine glands

increased thymocyte apoptosis ( J:100558 )

• thymocytes from mutant mice shows enhanced apoptosis to TCR/CD3 and Fas stimulation

• without stimulation, three- to fourfold increases of apoptotic cells in freshly isolated CD4+ and CD8+ single-positive thymocytes over the control cells (there was no such increase for mutant double-positive cells)