About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3589923
Allelic
Composition
Foxp3sf/Y
Genetic
Background
involves: STOCK MR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3sf mutation (6 available); any Foxp3 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 2/3 die before weaning and most of the rest shortly after weaning, though occasionally can live for several months
• the vast majority of mice that live past weaning die shortly thereafter

growth/size/body
• the few mice that live to adulthood are runty

reproductive system
• reddening of the genital papilla at P11
• testes are abdominal
• the few mice that live to adulthood are infertile (J:13126)
(J:14076)

vision/eye
• eyelids are delayed in opening

endocrine/exocrine glands
• testes are abdominal

integument
• first the tail, and then other parts of the body exhibit scaliness (J:13126)
• exhibit ichythosis (J:14076)
• mice also have tight skin

Mouse Models of Human Disease
OMIM ID Ref(s)
Ichthyosis and Male Hypogonadism 308200 J:14076
NOT Ichthyosis, X-Linked; XLI 308100 J:14076


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory