Phenotypes Associated with This Genotype

Genotype
MGI:3589923

• Allelic Composition: Foxp3^sf/Y
• Genetic Background: involves: STOCK MR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:13126 )

♂ • the vast majority of mice that live past weaning die shortly thereafter

postnatal lethality ( J:13126 )

♂ • 2/3 die before weaning and most of the rest shortly after weaning, though occasionally can live for several months

growth/size/body

decreased body size ( J:13126 )

♂ • the few mice that live to adulthood are runty

reproductive system

abnormal male reproductive system morphology ( J:13126 )

♂ • reddening of the genital papilla at P11

absent prostate gland anterior lobe ( J:14076 )

♂

absent seminal vesicle ( J:14076 )

♂

cryptorchism ( J:14076 )

♂ • testes are abdominal

absent scrotum ( J:14076 )

♂

small gonad ( J:14076 )

♂

small testis ( J:14076 )

♂

male infertility ( J:13126 , J:14076 )

♂ • the few mice that live to adulthood are infertile (J:13126)

♂ (J:14076)

vision/eye

delayed eyelid opening ( J:13126 )

♂ • eyelids are delayed in opening

endocrine/exocrine glands

absent prostate gland anterior lobe ( J:14076 )

♂

absent seminal vesicle ( J:14076 )

♂

small testis ( J:14076 )

♂

cryptorchism ( J:14076 )

♂ • testes are abdominal

integument

scaly skin ( J:13126 , J:14076 )

♂ • first the tail, and then other parts of the body exhibit scaliness (J:13126)

♂ • exhibit ichythosis (J:14076)

tight skin ( J:13126 )

♂ • mice also have tight skin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	X-linked ichthyosis	DOID:1700	OMIM:308100	J:14076