Phenotypes Associated with This Genotype

Genotype
MGI:3589876

• Allelic Composition: Wnt9b^tm1Amc/Wnt9b^tm1Amc
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:151498 )

• all mice die within 1 months of birth

renal/urinary system

kidney cyst ( J:151498 )

• cystic tubules

• pronounced cysts by P1

renal glomerulus cyst ( J:151498 )

abnormal kidney collecting duct epithelium morphology ( J:151498 )

• collecting duct epithelial cells exhibit randomized elongation unlike in wild-type mice

small kidney ( J:100575 )

• small kidneys with few mature nephrons are seen

abnormal renal tubule morphology ( J:151498 )

• severely dilated and cystic tubules

• kidney tubule diameter is decreased at E15.5, E17.5 and P1

dilated renal tubule ( J:151498 )

• as early as E15.5

• severe

• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct

growth/size/body

kidney cyst ( J:151498 )

• cystic tubules

• pronounced cysts by P1

renal glomerulus cyst ( J:151498 )