Analysis Tools
immune system
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• Background Sensitivity: the magnitude of leukotriene inhibition in DBA/1LacJ mice is less than that observed in the 129 strain
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• at 21-56 days, homozygotes exhibit reduced severity of collagen-induced arthritis, with a ~73% decrease in total disease score relative to wild-type mice
• reduced severity is maintained even after injection of IL-1, which normally increases disease severity, despite normal serum anti-collagen antibody levels
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• homozygotes display reduced acute and chronic inflammatory responses
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skeleton
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• at 21-56 days, homozygotes exhibit reduced severity of collagen-induced arthritis, with a ~73% decrease in total disease score relative to wild-type mice
• reduced severity is maintained even after injection of IL-1, which normally increases disease severity, despite normal serum anti-collagen antibody levels
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homeostasis/metabolism
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• homozygotes are viable, fertile and phenotypically normal but fail to produce peptido-leukotrienes following zymosan-induced peritonitis
• as a result, homozygotes show ~50% reduction in plasma protein extravasation in the peritoneal cavity in response to zymosan-injection
• unexpectedly, 12(S)-hydroxyeicosatetraenoic acid (HETE) levels are slightly reduced
• at 30 min after i.p. zymosan injection, homozygotes produce no detectable levels of LTC4 or LTE4
• at 3 hrs after i.p. zymosan injection, homozygotes produce no detectable levels of LTB4
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• homozygotes exhibit high levels of prostaglandins following zymosan-induced peritonitis
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