Phenotypes Associated with This Genotype

Genotype
MGI:3589670

• Allelic Composition: Sox9^tm2Crm/Sox9^tm2Crm; Tg(WT1-cre)1Asc/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased hair follicle apoptosis ( J:100131 )

• increase of apoptosis in the precortex of the hair bulb

abnormal coat/ hair morphology ( J:100131 )

• different types of hair are impossible to distinguish

alopecia ( J:100131 )

• appear hairless in the caudal part of the body, however further observation shows the presence of small, atrophic hair

abnormal hair shaft morphology ( J:100131 )

• hair shaft is fragile as hair broke off easily

abnormal hair follicle morphology ( J:100131 )

• between P6 and P14, show a marked change in follicular epithelium

• by P8, show an increased cellularity in the dermis

• reduction in cell proliferation in the matrix region

abnormal hair follicle matrix region morphology ( J:100131 )

• by P8, show a decreased number of bulb matrix cells

abnormal hair follicle outer root sheath morphology ( J:100131 )

• increase of apoptosis in the lower part of the outer root sheath

abnormal hair follicle bulge morphology ( J:100131 )

• bulge (the hair stem cell compartment) of the outer root sheath is absent

decreased hair follicle number ( J:100131 )

• hair follicles remain after the first hair cycle, however their number is reduced with a marked decrease at P60

hair follicle degeneration ( J:100131 )

• degeneration of the hair follicle after the first hair cycle

thick epidermis ( J:100131 )

cellular

increased hair follicle apoptosis ( J:100131 )

• increase of apoptosis in the precortex of the hair bulb