Phenotypes Associated with This Genotype

Genotype
MGI:3589668

• Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk; Gdf11^tm1Clf/Gdf11^tm1Clf
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased retina ganglion cell number ( J:99244 )

• double mutant retinas display an expanded differentiated ganglion cell layer, similar to that observed in Gdf11^tm1Clf mutant retinas

• at E17.5, the neuroblastic layer of double mutant retinas shows a 3-fold increase in migrating ganglion cells relative to wild-type retinas

vision/eye

abnormal retina neuronal layer morphology ( J:99244 )

increased retina ganglion cell number ( J:99244 )

• double mutant retinas display an expanded differentiated ganglion cell layer, similar to that observed in Gdf11^tm1Clf mutant retinas

• at E17.5, the neuroblastic layer of double mutant retinas shows a 3-fold increase in migrating ganglion cells relative to wild-type retinas