Phenotypes Associated with This Genotype

Genotype
MGI:3589458

• Allelic Composition: Mus81^tm1Chmg/Mus81^tm1Chmg
• Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:100407 )

• homozygotes display increased sensitivity to mitomycin C-induced lethality but did not display premature aging, decreased life spans, or increased tumor incidence

cellular

decreased cell proliferation ( J:100407 )

• homozygous MEFs die after 3 - 5 days in culture with a significant decrease in cells with 4N DNA and increase in cells with sub-G1 content of DNA after 2 days in culture; however, homozygous mice are viable and display normal growth, immune function, and fertility

• retroviral expression of the viral protein E6 which promotes degradation of Trp53 allows homozygous MEFs to survive in culture although these cells display increased DNA damage and chromosomal aberrations

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:100407 )

• homozygotes display increased sensitivity to mitomycin C-induced lethality but did not display premature aging, decreased life spans, or increased tumor incidence